| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 11 |
|---|
| Ligand | BDBM82940 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose Response selectivity of inhibitors of Striatal-Enriched Phosphatase (STEP) in a SHP2 (PTPN11) Inhibition Assay |
|---|
| IC50 | 7430±n/a nM |
|---|
| Citation |  PubChem, PC Dose Response selectivity of inhibitors of Striatal-Enriched Phosphatase (STEP) in a SHP2 (PTPN11) Inhibition Assay PubChem Bioassay(2012)[AID] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 11 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 11 |
|---|
| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
|---|
| Type: | Protein phosphatase |
|---|
| Mol. Mass.: | 68443.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q06124 |
|---|
| Residue: | 593 |
|---|
| Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
|
|
|
|---|
| BDBM82940 |
|---|
| n/a |
|---|
| Name | BDBM82940 |
|---|
| Synonyms: | 2-[7-(2-bromobenzyl)oxy-2-keto-4,8-dimethyl-chromen-3-yl]acetic acid | 2-[7-[(2-bromophenyl)methoxy]-4,8-dimethyl-2-oxidanylidene-chromen-3-yl]ethanoic acid | 2-[7-[(2-bromophenyl)methoxy]-4,8-dimethyl-2-oxo-1-benzopyran-3-yl]acetic acid | 2-[7-[(2-bromophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid | MLS001213427 | SMR000540529 | cid_1295810 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17BrO5 |
|---|
| Mol. Mass. | 417.25 |
|---|
| SMILES | Cc1c(CC(O)=O)c(=O)oc2c(C)c(OCc3ccccc3Br)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
