Reaction Details |
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Target | 26S proteasome non-ATPase regulatory subunit 14 |
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Ligand | BDBM45071 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay |
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IC50 | 44700±5880 nM |
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Citation | PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID] |
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More Info.: | Get all data from this article, Assay Method |
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26S proteasome non-ATPase regulatory subunit 14 |
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Name: | 26S proteasome non-ATPase regulatory subunit 14 |
Synonyms: | 26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein |
Type: | Protein |
Mol. Mass.: | 34576.68 |
Organism: | Homo sapiens (Human) |
Description: | O00487 |
Residue: | 310 |
Sequence: | MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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BDBM45071 |
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n/a |
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Name | BDBM45071 |
Synonyms: | 3-[4-[(Z)-(2-amino-4-keto-2-thiazolin-5-ylidene)methyl]-3-(4-chlorophenyl)pyrazol-1-yl]propionic acid | 3-[4-[(Z)-(2-amino-4-oxo-1,3-thiazol-5-ylidene)methyl]-3-(4-chlorophenyl)pyrazol-1-yl]propanoic acid | 3-[4-[(Z)-(2-amino-4-oxo-5-thiazolylidene)methyl]-3-(4-chlorophenyl)-1-pyrazolyl]propanoic acid | 3-[4-[(Z)-(2-azanyl-4-oxidanylidene-1,3-thiazol-5-ylidene)methyl]-3-(4-chlorophenyl)pyrazol-1-yl]propanoic acid | 3-{3-(4-chlorophenyl)-4-[(Z)-(2-imino-4-oxo-1,3-thiazolidin-5-ylidene)methyl]-1H-pyrazol-1-yl}propanoic acid | MLS000585888 | SMR000207669 | cid_12004457 |
Type | Small organic molecule |
Emp. Form. | C16H13ClN4O3S |
Mol. Mass. | 376.817 |
SMILES | NC1=NC(=O)C(S1)=Cc1cn(CCC(O)=O)nc1-c1ccc(Cl)cc1 |w:7.8,t:1| |
Structure |
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