| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM88906 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay |
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| IC50 | 15100±4360 nM |
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| Citation |  PubChem, PC Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | THRB_BOVIN | Thrombin | Thrombin heavy chain | Thrombin light chain |
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| Type: | Enzyme |
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| Mol. Mass.: | 70502.73 |
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| Organism: | Bos taurus (Bovine) |
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| Description: | P00735 |
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| Residue: | 625 |
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| Sequence: | MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERE
CLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGN
VSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRRE
ECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSS
EQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDL
GDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFE
SYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNF
TVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDY
IHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCK
ASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRD
GKYGFYTHVFRLKKWIQKVIDRLGS
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| BDBM88906 |
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| n/a |
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| Name | BDBM88906 |
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| Synonyms: | 3-(4-Oxo-5-thiophen-2-ylmethylene-2-thioxo-thiazolidin-3-yl)-N-pyridin-2-yl-prop | 3-[(5E)-4-keto-5-(2-thenylidene)-2-thioxo-thiazolidin-3-yl]-N-(2-pyridyl)propionamide | 3-[(5E)-4-oxidanylidene-2-sulfanylidene-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-3-yl]-N-pyridin-2-yl-propanamide | 3-[(5E)-4-oxo-2-sulfanylidene-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-3-yl]-N-pyridin-2-ylpropanamide | 3-[(5E)-4-oxo-2-sulfanylidene-5-(thiophen-2-ylmethylidene)-3-thiazolidinyl]-N-(2-pyridinyl)propanamide | MLS000723767 | SMR000305362 | cid_1584574 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13N3O2S3 |
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| Mol. Mass. | 375.488 |
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| SMILES | O=C(CCN1C(=S)S\C(=C\c2cccs2)C1=O)Nc1ccccn1 |
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| Structure | 
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