Reaction Details | |||
---|---|---|---|
![]() | Report a problem with these data | ||
Target | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] | ||
Ligand | BDBM278594 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibitory Activity Against IDH1R132H and IDH1R132C Enzymes | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 107±n/a nM | ||
Comments | extracted | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] | |||
Name: | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] | ||
Synonyms: | IDH1 | IDH1 R132C | IDH1(R132C) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132C) | Isocitrate dehydrogenase 1 mutant (R132C) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) (R132C) | PICD | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 46607.23 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75874[R132C] | ||
Residue: | 414 | ||
Sequence: |
| ||
BDBM278594 | |||
n/a | |||
Name | BDBM278594 | ||
Synonyms: | (2E)-3-(1-{[3-(2,6-Dichloro-4- methylphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid | US10040791, Example 56 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H21Cl2FN2O4 | ||
Mol. Mass. | 515.36 | ||
SMILES | Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(C)cc2Cl)c2cccc(\C=C\C(O)=O)c12 |(3.9,1.01,;2.57,.24,;1.13,.79,;.16,-.41,;-1.38,-.41,;-2.15,-1.74,;-2.15,.93,;-3.69,.93,;-4.16,2.39,;-2.92,3.3,;-1.67,2.39,;-.18,2.79,;.91,1.7,;.22,4.28,;1.3,3.19,;-4.77,-.16,;-6.26,.24,;-6.66,1.72,;-7.35,-.85,;-6.95,-2.34,;-8.04,-3.43,;-5.47,-2.74,;-4.38,-1.65,;-2.89,-2.05,;1,-1.7,;.6,-3.19,;1.69,-4.28,;3.18,-3.88,;3.58,-2.39,;5.07,-1.99,;5.47,-.5,;6.95,-.11,;8.04,-1.19,;7.35,1.38,;2.49,-1.3,)| | ||
Structure | ![]() |