Ki Summary

Reaction Details

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Target

Corticotropin-releasing factor-binding protein

Ligand

BDBM51964

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex

EC50

>53000±n/a nM

Citation

PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay(2012)[AID]

More Info.:

Get all data from this article, Assay Method

Corticotropin-releasing factor-binding protein

Name:

Corticotropin-releasing factor-binding protein

Synonyms:

CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

36143.95

Organism:

Homo sapiens (Human)

Description:

P24387

Residue:

322

Sequence:

MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRC
LDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKG
EKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNL
FPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGI
GDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQ
LEPYELENPNGNSIGEFCLSGL

BDBM51964

n/a

Name

BDBM51964

Synonyms:

2-{[(4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]thio}-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one | 3-[(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methylsulfanyl]-2,6,7,8-tetrahydrocyclopenta[2,3]thieno[2,4-b]pyrimidin-1-one | 3-[(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methylthio]-2,6,7,8-tetrahydrocyclopenta[2,3]thieno[2,4-b]pyrimidin-1-one | 3-[(4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)methylthio]-2,6,7,8-tetrahydrocyclopenta[2,3]thieno[2,4-b]pyrimidin-1-one | MLS000531546 | SMR000136544 | cid_2229949

Type

Small organic molecule

Emp. Form.

C18H15N5OS3

Mol. Mass.

413.54

SMILES

O=c1[nH]c(SCc2n[nH]c(=S)n2-c2ccccc2)nc2sc3CCCc3c12

Structure