| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sentrin-specific protease 8 |
|---|
| Ligand | BDBM70614 |
|---|
| Substrate/Competitor | n/a |
|---|
| IC50 | 14700±1680 nM |
|---|
| Citation |  PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay(2012)[AID] |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Sentrin-specific protease 8 |
|---|
| Name: | Sentrin-specific protease 8 |
|---|
| Synonyms: | DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 24104.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_262118306 |
|---|
| Residue: | 212 |
|---|
| Sequence: | MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQ
FIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDS
HSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFR
QQTESLLQLLTPAYITKKRGEWKDLITTLAKK
|
|
|
|---|
| BDBM70614 |
|---|
| n/a |
|---|
| Name | BDBM70614 |
|---|
| Synonyms: | 2-(3,4-dimethylphenyl)-4-[[1-(3,4-dimethylphenyl)-3-methyl-5-oxidanylidene-4H-pyrazol-4-yl]-(3-hydroxyphenyl)methyl]-5-methyl-4H-pyrazol-3-one | 2-(3,4-dimethylphenyl)-4-[[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4H-pyrazol-4-yl]-(3-hydroxyphenyl)methyl]-5-methyl-4H-pyrazol-3-one | 2-(3,4-dimethylphenyl)-4-[[1-(3,4-dimethylphenyl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl](3-hydroxyphenyl)methyl]-5-methyl-2,4-dihydro-3H-pyrazol-3-one | 2-(3,4-dimethylphenyl)-4-[[1-(3,4-dimethylphenyl)-5-keto-3-methyl-2-pyrazolin-4-yl]-(3-hydroxyphenyl)methyl]-5-methyl-2-pyrazolin-3-one | MLS000539675 | SMR000161977 | cid_3252210 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H32N4O3 |
|---|
| Mol. Mass. | 508.6108 |
|---|
| SMILES | Cc1[nH]n(-c2ccc(C)c(C)c2)c(=O)c1C(c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O)c1cccc(O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
