| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM93628 |
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| Substrate/Competitor | n/a |
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| IC50 | 2150±132 nM |
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| Citation |  PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 in a Caspase-3 Fluorescence assay PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article |
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| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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| BDBM93628 |
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| n/a |
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| Name | BDBM93628 |
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| Synonyms: | 5-amino-4-keto-N-[(E)-p-anisylideneamino]-3-phenyl-thieno[3,4-d]pyridazine-1-carboxamide | 5-amino-N'-(4-methoxybenzylidene)-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carbohydrazide | 5-amino-N-[(E)-(4-methoxyphenyl)methylideneamino]-4-oxo-3-phenyl-1-thieno[3,4-d]pyridazinecarboxamide | 5-amino-N-[(E)-(4-methoxyphenyl)methylideneamino]-4-oxo-3-phenylthieno[3,4-d]pyridazine-1-carboxamide | 5-azanyl-N-[(E)-(4-methoxyphenyl)methylideneamino]-4-oxidanylidene-3-phenyl-thieno[3,4-d]pyridazine-1-carboxamide | MLS000545662 | SMR000164098 | cid_6871359 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17N5O3S |
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| Mol. Mass. | 419.456 |
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| SMILES | COc1ccc(\C=N\NC(=O)c2nn(-c3ccccc3)c(=O)c3c(N)scc23)cc1 |
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| Structure | 
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