| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM61232 |
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| Substrate/Competitor | n/a |
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| IC50 | 407±26 nM |
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| Citation |  PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 in a Caspase-3 Fluorescence assay PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article |
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| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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| BDBM61232 |
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| n/a |
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| Name | BDBM61232 |
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| Synonyms: | (2-bromanyl-4,5-dimethoxy-phenyl)-(6,7-dimethoxyisoquinolin-1-yl)methanone | (2-bromo-4,5-dimethoxy-phenyl)-(6,7-dimethoxy-1-isoquinolyl)methanone | (2-bromo-4,5-dimethoxyphenyl)(6,7-dimethoxy-1-isoquinolinyl)methanone | (2-bromo-4,5-dimethoxyphenyl)-(6,7-dimethoxy-1-isoquinolinyl)methanone | (2-bromo-4,5-dimethoxyphenyl)-(6,7-dimethoxyisoquinolin-1-yl)methanone | MLS001001832 | SMR000498332 | cid_2974206 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18BrNO5 |
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| Mol. Mass. | 432.265 |
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| SMILES | COc1cc(Br)c(cc1OC)C(=O)c1nccc2cc(OC)c(OC)cc12 |
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| Structure | 
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