Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM106516

Substrate/Competitor

n/a

Meas. Tech.

Radioligand Binding Assay

72.7±0.0 nM

Citation

Gobbi, L; Rodriguez Sarmiento, RM; Wichmann, J Anellated pyridine compounds US Patent US8586579 Publication Date 11/19/2013

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM106516

n/a

Name

BDBM106516

Synonyms:

US8586579, 105

Type

Small organic molecule

Emp. Form.

C26H38N4O3

Mol. Mass.

454.6049

SMILES

Cc1cnc(N2CCN(CC[C@H]3CC[C@@H](CC3)NC(=O)C3CCOCC3)CC2)c2ccoc12 |r,wU:14.17,wD:11.10,(-11.55,.52,;-10.01,.52,;-9.24,1.85,;-7.7,1.85,;-6.93,.52,;-5.39,.52,;-4.62,-.82,;-3.08,-.82,;-2.31,.52,;-.77,.52,;,1.85,;1.54,1.85,;2.31,.52,;3.85,.52,;4.62,1.85,;3.85,3.19,;2.31,3.19,;6.16,1.85,;6.93,.52,;6.16,-.82,;8.47,.52,;9.24,-.82,;10.78,-.82,;11.55,.52,;10.78,1.85,;9.24,1.85,;-3.08,1.85,;-4.62,1.85,;-7.7,-.82,;-7.22,-2.28,;-8.47,-3.19,;-9.72,-2.28,;-9.24,-.82,)|

Structure