| Reaction Details |
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 | Report a problem with these data |
| Target | Guanylate cyclase soluble subunit alpha-1 |
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| Ligand | BDBM281728 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Stimulation of sGC Enzyme Activity |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| EC50 | 22.0±n/a nM |
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| Comments | extracted |
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| Citation |  Hahn, M; Lampe, T; Stasch, J; Schlemmer, K; Wunder, F; Li, VM; Becker-Pelster, E; Stoll, F; Knorr, A; Woltering, E Branched 3-phenylpropionic acid derivatives and their use US Patent US10023528 Publication Date 7/17/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Guanylate cyclase soluble subunit alpha-1 |
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| Name: | Guanylate cyclase soluble subunit alpha-1 |
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| Synonyms: | GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC) |
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| Type: | Enzyme |
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| Mol. Mass.: | 77457.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02108 |
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| Residue: | 690 |
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| Sequence: | MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
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| BDBM281728 |
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| n/a |
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| Name | BDBM281728 |
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| Synonyms: | (+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluo-3-methylbutanoyl]amino}phenyl)-4-methylpentanoic acid (diastereomer 1) | US10023528, Example 1 | US10259776, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24Cl2F3NO3 |
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| Mol. Mass. | 490.343 |
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| SMILES | CC(C)C(CC(O)=O)c1ccc(Cl)c(NC(=O)[C@@H]([C@@H](C)C(F)(F)F)c2ccc(Cl)cc2)c1 |r| |
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| Structure | 
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