Reaction Details |
| Report a problem with these data |
Target | 5-hydroxytryptamine receptor 6 |
---|
Ligand | BDBM50417911 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Functional Assay |
---|
IC50 | 912±n/a nM |
---|
Citation | Ivashchenko, AA; Savchuk, NF; Ivashchenko, AV; Lavrovsky, Y; Mitkin, OD; Kadieva, MG Substituted 3-arylsulfonyl-pyrazolo[1,5-A]pyrimidines, serotonin 5-HT6 receptor antagonists and methods for the production and use thereof US Patent US8618114 Publication Date 12/31/2013 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
5-hydroxytryptamine receptor 6 |
---|
Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
|
|
|
BDBM50417911 |
---|
n/a |
---|
Name | BDBM50417911 |
Synonyms: | CHEMBL1668579 | US8618114, 1.1.1(4) |
Type | Small organic molecule |
Emp. Form. | C13H9ClFN3O2S2 |
Mol. Mass. | 357.811 |
SMILES | CSc1nn2cccnc2c1S(=O)(=O)c1ccc(F)c(Cl)c1 |
Structure |
|