| Reaction Details |
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 | Report a problem with these data |
| Target | Disintegrin and metalloproteinase domain-containing protein 10 |
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| Ligand | BDBM113975 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10. |
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| IC50 | 7729±n/a nM |
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| Citation |  PubChem, PC QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10. PubChem Bioassay(2014)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Disintegrin and metalloproteinase domain-containing protein 10 |
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| Name: | Disintegrin and metalloproteinase domain-containing protein 10 |
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| Synonyms: | ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM |
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| Type: | Enzyme |
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| Mol. Mass.: | 84160.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14672 |
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| Residue: | 748 |
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| Sequence: | MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
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| BDBM113975 |
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| n/a |
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| Name | BDBM113975 |
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| Synonyms: | 2-amino-5-benzoyl-N-[2-(1H-indol-3-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide | 2-azanyl-N-[2-(1H-indol-3-yl)ethyl]-5-(phenylcarbonyl)-4-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide | MLS003826388 | N-(2-(1H-indol-3-yl)ethyl)-2-amino-5-benzoyl-4-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide | SMR002504575 | cid_56588246 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H23F3N4O2 |
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| Mol. Mass. | 516.5137 |
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| SMILES | Nc1[nH]c(C(=O)c2ccccc2)c(c1C(=O)NCCc1c[nH]c2ccccc12)-c1cccc(c1)C(F)(F)F |
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| Structure | 
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