| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 2 |
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| Ligand | BDBM64787 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) |
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| IC50 | 9102±n/a nM |
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| Citation |  PubChem, PC Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) PubChem Bioassay(2014)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Tyrosyl-DNA phosphodiesterase 2 |
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| Name: | Tyrosyl-DNA phosphodiesterase 2 |
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| Synonyms: | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40916.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_23510348 |
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| Residue: | 362 |
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| Sequence: | MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
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|
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| BDBM64787 |
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| n/a |
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| Name | BDBM64787 |
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| Synonyms: | 2-(1-Acetyl-2-oxo-propyl)-2-hydroxy-indan-1,3-dione | 2-(1-acetyl-2-keto-propyl)-2-hydroxy-indane-1,3-quinone | 2-(2,4-dioxopentan-3-yl)-2-hydroxyindene-1,3-dione | 2-[2,4-bis(oxidanylidene)pentan-3-yl]-2-oxidanyl-indene-1,3-dione | MLS000588745 | SMR000212365 | cid_766079 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H12O5 |
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| Mol. Mass. | 260.2421 |
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| SMILES | CC(=O)C(C(C)=O)C1(O)C(=O)c2ccccc2C1=O |
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| Structure | 
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