Reaction Details |
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Target | Urea transporter 2 |
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Ligand | BDBM115187 |
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Substrate/Competitor | n/a |
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Meas. Tech. | UT-A1 Inhibition Assay |
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IC50 | 1.9e+4±n/a nM |
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Citation | Esteva-Font, C; Phuan, PW; Anderson, MO; Verkman, AS A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol20:1235-44 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Urea transporter 2 |
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Name: | Urea transporter 2 |
Synonyms: | Slc14a2 | UT2_RAT | Urea transporter 2 | Urea transporter A1 (UT-A1) | Ut2 |
Type: | Protein |
Mol. Mass.: | 101906.19 |
Organism: | Rattus norvegicus (Rat) |
Description: | n/a |
Residue: | 929 |
Sequence: | MSDHPLKEMSDNNRSPPLPEPLSSRYKLYESELSSPTWPSSSQDTHPALPLLEMPEEKDL
RSSDEDSHIVKIEKPNERSKRRESELPRRASAGRGAFSLFQAVSYLTGDMKECKNWLKDK
PLVLQFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQ
DRSAIASGLHGYNGMLVGLLVAVFSEKLDYYWWLLFPVTFASMACPVISSALSTVFAKWD
LPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSEIEMPLLLQTIPVGVGQ
VYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVL
SCVAIGGMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFCLSTLTFLLL
TSNNPGIHKLPLSKVTYPEANRIYFLTAKRSDEQKPPNGGGGEQSHGGGQRKAEEGSETV
FPRRKSVFHIEWSSIRRRSKVFGKSEHQERQTKEPLPYLYRKPTVELLDLNTMEESSEIK
VETNTTRTTWIQSSMIAGGKRVSKALSYITGEMKECGEGLKDKSPVFQFLDWVLRGTSQV
MFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLV
GLLMAVFSDKGNYYWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLA
ATGHYNLFFPTKLLQPAVTTPNITWSDVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVAL
FVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTH
LLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPGIYKLPLSKVTY
PEANRIYFLSQEKNRRASMITKYQAYDVS
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BDBM115187 |
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n/a |
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Name | BDBM115187 |
Synonyms: | N‐(3‐chloro‐4‐methoxyphenyl)‐8‐methoxy‐2‐ (thiomorpholine‐4‐carbonyl)quinolin‐4‐amine | UT-A1 inhibitor A6 |
Type | Small organic molecule |
Emp. Form. | C22H22ClN3O3S |
Mol. Mass. | 443.946 |
SMILES | COc1ccc(Nc2cc(nc3c(OC)cccc23)C(=O)N2CCSCC2)cc1Cl |
Structure |
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