| Reaction Details |
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 | Report a problem with these data |
| Target | Urea transporter 2 |
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| Ligand | BDBM115194 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | UT-A1 Inhibition Assay |
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| IC50 | 4.2e+3±n/a nM |
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| Citation |  Esteva-Font, C; Phuan, PW; Anderson, MO; Verkman, AS A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol20:1235-44 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urea transporter 2 |
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| Name: | Urea transporter 2 |
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| Synonyms: | Slc14a2 | UT2_RAT | Urea transporter 2 | Urea transporter A1 (UT-A1) | Ut2 |
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| Type: | Protein |
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| Mol. Mass.: | 101906.19 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | n/a |
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| Residue: | 929 |
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| Sequence: | MSDHPLKEMSDNNRSPPLPEPLSSRYKLYESELSSPTWPSSSQDTHPALPLLEMPEEKDL
RSSDEDSHIVKIEKPNERSKRRESELPRRASAGRGAFSLFQAVSYLTGDMKECKNWLKDK
PLVLQFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQ
DRSAIASGLHGYNGMLVGLLVAVFSEKLDYYWWLLFPVTFASMACPVISSALSTVFAKWD
LPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSEIEMPLLLQTIPVGVGQ
VYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVL
SCVAIGGMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFCLSTLTFLLL
TSNNPGIHKLPLSKVTYPEANRIYFLTAKRSDEQKPPNGGGGEQSHGGGQRKAEEGSETV
FPRRKSVFHIEWSSIRRRSKVFGKSEHQERQTKEPLPYLYRKPTVELLDLNTMEESSEIK
VETNTTRTTWIQSSMIAGGKRVSKALSYITGEMKECGEGLKDKSPVFQFLDWVLRGTSQV
MFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLV
GLLMAVFSDKGNYYWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLA
ATGHYNLFFPTKLLQPAVTTPNITWSDVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVAL
FVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTH
LLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPGIYKLPLSKVTY
PEANRIYFLSQEKNRRASMITKYQAYDVS
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| BDBM115194 |
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| n/a |
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| Name | BDBM115194 |
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| Synonyms: | 4‐(4,5‐dihydro‐1,3‐thiazol‐2‐ylsulfanyl)‐N‐(3,4‐ dimethoxyphenyl)‐6‐[(3,4‐dimethoxyphenyl)methyl]‐ 1,3,5‐triazin‐2‐amine | UT-A1 inhibitor C1 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25N5O4S2 |
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| Mol. Mass. | 499.606 |
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| SMILES | COc1ccc(Cc2nc(Nc3ccc(OC)c(OC)c3)nc(SC3=NCCS3)n2)cc1OC |t:25| |
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| Structure | 
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