| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B |
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| Ligand | BDBM123823 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human MAO inhibitory test |
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| pH | 7.4±0 |
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| Temperature | 310.15±0 K |
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| Ki | 3.1e+3± 8.7e+2 nM |
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| Citation |  Rane, RA; Napahde, S; Bangalore, PK; Sahu, NU; Shah, N; Kulkarni, YA; Barve, K; Lokare, L; Karpoormath, R Synthesis and evaluation of novel marine bromopyrrole alkaloid-based derivatives as potential antidepressant agents. Chem Biol Drug Des84:593-602 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] B |
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| Name: | Amine oxidase [flavin-containing] B |
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| Synonyms: | AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB) |
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| Type: | Protein |
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| Mol. Mass.: | 58768.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27338 |
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| Residue: | 520 |
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| Sequence: | MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
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| BDBM123823 |
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| n/a |
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| Name | BDBM123823 |
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| Synonyms: | 4,5-dibromo-N'-[(2,4-dichlorophenyl)methylidene]-1H-pyrrole-2-carbohydrazide (4j) |
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| Type | Small organic molecule |
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| Emp. Form. | C12H7Br2Cl2N3O |
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| Mol. Mass. | 439.917 |
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| SMILES | Clc1ccc(C=NNC(=O)c2cc(Br)c(Br)[nH]2)c(Cl)c1 |w:6.6| |
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| Structure | 
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