Ki Summary

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Target

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Ligand

BDBM144676

Substrate/Competitor

n/a

Meas. Tech.

IMAP TR-FRET Assay

Temperature

298.15±n/a K

IC50

1.94±n/a nM

Comments

extracted

Citation

Allen, JR; Frohn, MJ; Harrington, PE; Hu, E; Pickrell, AJ; Rzasa, RM; Sham, KK Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors US Patent US8952037 Publication Date 2/10/2015

More Info.:

Get all data from this article, Assay Method

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Name:

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Synonyms:

Type:

Protein

Mol. Mass.:

88412.52

Organism:

Homo sapiens (Human)

Description:

Q9Y233

Residue:

1055

Sequence:

MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAE
RAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWP
PPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSS
HRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGG
GGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLS
LHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQ
RLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGP
ITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGIL
ELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNI
VAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRF
SIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQM
VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE
EWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMS
VKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSY
LQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATD
LALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA
EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKA
CRDNLSQWEKVIRGEETATWISSPSVAQKAAASED

BDBM144676

n/a

Name

BDBM144676

Synonyms:

US8952037, 49

Type

Small organic molecule

Emp. Form.

C21H19N5OS

Mol. Mass.

389.473

SMILES

Cc1ncccc1-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:14.15,16.20,(-3.32,.77,;-4.65,1.54,;-4.65,3.08,;-5.98,3.85,;-7.32,3.08,;-7.32,1.54,;-5.98,.77,;-5.98,-.77,;-7.32,-1.54,;-7.32,-3.08,;-5.98,-3.85,;-4.65,-3.08,;-4.65,-1.54,;-3.32,-.77,;-1.98,-1.54,;-1.58,-3.03,;-.1,-2.63,;-.5,-1.14,;1.24,-3.4,;2.57,-2.63,;2.73,-1.1,;4.24,-.78,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,)|

Structure