| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM180846 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CDK2/CycE Kinase Assay |
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| pH | 8±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 410±n/a nM |
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| Comments | extracted |
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| Citation |  Lücking, U; Kosemund, D; Scholz, A; Lienau, P; Siemeister, G; Bömer, U; Bohlmann, R Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group US Patent US9133171 Publication Date 9/15/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM180846 |
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| n/a |
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| Name | BDBM180846 |
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| Synonyms: | US9133171, 51 | US9133171, 52 | US9133171, 53 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19F3N4O2S |
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| Mol. Mass. | 448.461 |
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| SMILES | COc1cc(F)ccc1-c1nc(Nc2cc(F)cc(CS(=N)(=O)C3CC3)c2)ncc1F |
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| Structure | 
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