| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM192570 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PIM Enzyme Assay |
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| IC50 | 4±n/a nM |
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| Citation |  D'amico, DC; Herberich, BJ; Jackson, CL; Pettus, LH; Tasker, A; Wang, H; Wu, B; Wurz, R Bicyclic pyridazine compounds as Pim inhibitors US Patent US9187486 Publication Date 11/17/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM192570 |
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| n/a |
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| Name | BDBM192570 |
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| Synonyms: | US9187486, 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22F2N6 |
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| Mol. Mass. | 420.4578 |
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| SMILES | N[C@H]1CCC[C@H](C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| |
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| Structure | 
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