| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [1-745,751-967] |
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| Ligand | BDBM202384 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell Based Assay |
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| EC50 | <10±n/a nM |
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| Citation |  Lee, K; Niu, D; Petter, RC; Singh, J Heteroaryl compounds and uses thereof US Patent US9238629 Publication Date 1/19/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [1-745,751-967] |
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| Name: | Epidermal growth factor receptor [1-745,751-967] |
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| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) (delE746-A750) | HER1 |
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| Type: | n/a |
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| Mol. Mass.: | 106734.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[1-745,751-967] |
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| Residue: | 962 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTST
VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV
KTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVW
ELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELI
IE
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| BDBM202384 |
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| n/a |
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| Name | BDBM202384 |
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| Synonyms: | US10081606, Compound I-16 | US9238629, I-16 | US9765038, Compound I-16 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20F3N5O3 |
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| Mol. Mass. | 459.4211 |
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| SMILES | COc1cccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c1OC |
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| Structure | 
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