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TargetSRSF protein kinase 1
LigandBDBM221070
Substrate/Competitorn/a
Meas. Tech.In Vitro Kinase Screening Assay
pH7.5±n/a
Temperature303.15±n/a K
IC50 880±0.0 nM
Commentsextracted
Citation Batson, JToop, HDRedondo, CBabaei-Jadidi, RChaikuad, AWearmouth, SFGibbons, BAllen, CTallant, CZhang, JDu, CHancox, JCHawtrey, TDa Rocha, JGriffith, RKnapp, SBates, DOMorris, JC Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem Biol12:825-832 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
SRSF protein kinase 1
Name:SRSF protein kinase 1
Synonyms:SRPK1 | SRPK1_HUMAN | SRSF protein kinase 1 (SRPK1) | Serine/arginine-protein kinase 1 (SRPK1) | Serine/threonine-protein kinase SRPK1
Type:Protein
Mol. Mass.:74318.38
Organism:Homo sapiens (Human)
Description:Q96SB4
Residue:655
Sequence:
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPN
DYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTET
ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSN
YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQR
SGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ
KRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVI
EVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSE
VSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLV
NPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACM
AFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHI
TKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM221070
n/a
NameBDBM221070
Synonyms:SPHINX | US9695160, SPHINX | US9796707, Reference Compound SPHINX
TypeSmall organic molecule
Emp. Form.C17H17F3N2O3
Mol. Mass.354.3237
SMILESCc1ccc(o1)C(=O)Nc1cc(ccc1N1CCOCC1)C(F)(F)F
Structure
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