| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
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| Ligand | BDBM50401614 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DELFIA® Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 6±n/a nM |
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| Comments | extracted |
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| Citation |  Collins, I; Lainchbury, M; Matthews, TP; Reader, JC 5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use US Patent US9403797 Publication Date 8/2/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Serine/threonine-protein kinase Chk1 |
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| Name: | Serine/threonine-protein kinase Chk1 |
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| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54443.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_166295192 |
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| Residue: | 476 |
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| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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|
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| BDBM50401614 |
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| n/a |
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| Name | BDBM50401614 |
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| Synonyms: | CHEMBL2203843 | US9403797, PAPC-A-01 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N8O2 |
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| Mol. Mass. | 408.457 |
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| SMILES | COc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1-c1cnn(C)c1 |r| |
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| Structure | 
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