| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM238545 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogeneous Time Resolved Fluorescence Assay (HTRF) |
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| pH | 7±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 9.3±n/a nM |
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| Comments | extracted |
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| Citation |  Cee, V; Chavez, Jr., F; Chen, JJ; Harrington, EH; Herberich, B; Jackson, CL; Lanman, BA; Nguyen, TT; Norman, MH; Pettus, LH; Reed, AB; Smith, AL; Tamayo, NA; Tasker, A; Wang, H; Wu, B; Wurz, R Amides as pim inhibitors US Patent US9394297 Publication Date 7/19/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM238545 |
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| n/a |
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| Name | BDBM238545 |
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| Synonyms: | US9394297, 191 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N5O |
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| Mol. Mass. | 335.4029 |
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| SMILES | CCCNc1nc2c(cccc2nc1C)-c1cc2c(CCNC2=O)[nH]1 |
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| Structure | 
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