Reaction Details |
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Target | Inosine-5'-monophosphate dehydrogenase 2 |
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Ligand | BDBM248105 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Assay |
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pH | 8±0 |
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Temperature | 310.15±0 K |
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IC50 | <3e+4±0 nM |
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Citation | Dunkern, T; Chavan, S; Bankar, D; Patil, A; Kulkarni, P; Kharkar, PS; Prabhu, A; Goebel, H; Rolser, E; Burckhard-Boer, W; Arumugam, P; Makhija, MT Design, synthesis and biological evaluation of novel inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors. J Enzyme Inhib Med Chem29:408-19 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Inosine-5'-monophosphate dehydrogenase 2 |
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Name: | Inosine-5'-monophosphate dehydrogenase 2 |
Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Type: | Enzyme |
Mol. Mass.: | 55806.87 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant IMPDH2 expressed in E. coli. |
Residue: | 514 |
Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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BDBM248105 |
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n/a |
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Name | BDBM248105 |
Synonyms: | IMPDH II inhibitor, 22 |
Type | Small organic molecule |
Emp. Form. | C24H26N6O4 |
Mol. Mass. | 462.501 |
SMILES | CCC(CC#N)OC(=O)N[C@@H](C)c1cccc(NC(=O)Nc2ccc3ncc(OC)nc3c2)c1 |r| |
Structure |
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