Reaction Details |
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Target | Glutaminyl-peptide cyclotransferase |
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Ligand | BDBM259915 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorometric Assays |
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pH | 8±n/a |
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Temperature | 303.15±n/a K |
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Ki | 2.5297±n/a nM |
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Comments | extracted |
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Citation | Heiser, U; Buchholz, M; Sommer, R; Meyer, A; Demuth, H Inhibitors US Patent US9512115 Publication Date 12/6/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Glutaminyl-peptide cyclotransferase |
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Name: | Glutaminyl-peptide cyclotransferase |
Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 40877.05 |
Organism: | Homo sapiens (Human) |
Description: | Q16769 |
Residue: | 361 |
Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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BDBM259915 |
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n/a |
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Name | BDBM259915 |
Synonyms: | US9512115, 19 |
Type | Small organic molecule |
Emp. Form. | C20H16F4N4O2 |
Mol. Mass. | 420.3603 |
SMILES | Fc1c(F)c(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1 |r| |
Structure |
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