| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
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| Ligand | BDBM50054265 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7±n/a |
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| IC50 | 3600±300 nM |
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| Comments | extracted |
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| Citation |  Zhang, Z; Zeng, L Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) US Patent US9522881 Publication Date 12/20/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
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| Name: | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
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| Synonyms: | INPPL-1 | INPPL1 | Inositol polyphosphate phosphatase-like protein 1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | Protein 51C | SH2 domain-containing inositol phosphatase 2 | SHIP-2 | SHIP2 | SHIP2_HUMAN | Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 138596.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15357 |
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| Residue: | 1258 |
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| Sequence: | MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST
VSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS
SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS
TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT
HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE
PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE
WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN
KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT
HLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT
YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSP
VFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKS
FENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVA
LKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKS
KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPR
LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT
VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGR
GGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGP
ARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAG
MSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK
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| BDBM50054265 |
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| n/a |
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| Name | BDBM50054265 |
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| Synonyms: | CHEMBL3319384 | US9522881, 11c-2 (L88M49) |
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| Type | Small organic molecule |
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| Emp. Form. | C32H26IN3O6 |
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| Mol. Mass. | 675.4698 |
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| SMILES | Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)CCC(=O)Nc2ccc(Oc3ccccc3)cc2)c1 |
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| Structure | 
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