Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM260748 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ADP-Glo Kinase Assay |
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IC50 | 24.3±n/a nM |
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Citation | Whitlock, GA; Glossop, PA Substituted pyrimidine-5-carboxamides as spleen tyrosine kinase inhibitors US Patent US9533989 Publication Date 1/3/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM260748 |
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n/a |
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Name | BDBM260748 |
Synonyms: | US9533989, 59 |
Type | Small organic molecule |
Emp. Form. | C25H26N6O2 |
Mol. Mass. | 442.5129 |
SMILES | N[C@H]1CCCC[C@H]1Nc1nc(Nc2cccc(c2)-c2ccc(O)cc2)c2c(cc[nH]c2=O)n1 |
Structure |
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