Reaction Details |
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Target | Kallikrein-1 |
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Ligand | BDBM408666 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibitory Activity In Vitro Assay |
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IC50 | >10000±n/a nM |
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Citation | Davie, RL; Edwards, HJ; Evans, DM; Hodgson, ST N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors US Patent US10364238 Publication Date 7/30/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Kallikrein-1 |
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Name: | Kallikrein-1 |
Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
Type: | Enzyme |
Mol. Mass.: | 28874.69 |
Organism: | Homo sapiens (Human) |
Description: | P06870 |
Residue: | 262 |
Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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BDBM408666 |
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n/a |
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Name | BDBM408666 |
Synonyms: | 3-Amino-1-[4-(2-oxo-2H-pyridin-1-ylmethyl)-benzyl]-1H-pyrazole-4-carboxylic acid 2-fluoro-3-methoxy-benzylamide | US10364238, Example 2 | US11001578, Example 2 | US11084809, Example 2 | US11198691, Example 2 |
Type | Small organic molecule |
Emp. Form. | C25H24FN5O3 |
Mol. Mass. | 461.4882 |
SMILES | COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N)c1F |
Structure |
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