| Reaction Details |
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 | Report a problem with these data |
| Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Ligand | BDBM409907 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Kinetic Assay |
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| IC50 | >1000±n/a nM |
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| Citation |  Pinkerton, AB; Dahl, R; Cosford, ND; Millan, JL Sulfonamide compounds and uses as TNAP inhibitors US Patent US10370333 Publication Date 8/6/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Alkaline phosphatase, tissue-nonspecific isozyme |
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| Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57306.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1448917 |
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| Residue: | 524 |
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| Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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| BDBM409907 |
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| n/a |
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| Name | BDBM409907 |
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| Synonyms: | US10370333, Example XI-16 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13F3N2O4S2 |
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| Mol. Mass. | 430.421 |
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| SMILES | COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)-c1cccs1 |
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| Structure | 
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