| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor TYRO3 |
|---|
| Ligand | BDBM396953 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TAM Enzymatic Assay |
|---|
| IC50 | 55±n/a nM |
|---|
| Citation |  Li, Y; Wang, X; He, C Pyrrolotriazine compounds as TAM inhibitors US Patent US10442810 Publication Date 10/15/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase receptor TYRO3 |
|---|
| Name: | Tyrosine-protein kinase receptor TYRO3 |
|---|
| Synonyms: | BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 96894.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q06418 |
|---|
| Residue: | 890 |
|---|
| Sequence: | MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
|
|
|
|---|
| BDBM396953 |
|---|
| n/a |
|---|
| Name | BDBM396953 |
|---|
| Synonyms: | US10442810, Example 15 | US10844069, Example 15 | US11591338, Example 15 | US9981975, Example 15 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H25FN6O3 |
|---|
| Mol. Mass. | 524.5456 |
|---|
| SMILES | Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
