Reaction Details |
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Target | Glutaminase kidney isoform, mitochondrial |
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Ligand | BDBM416686 |
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Substrate/Competitor | n/a |
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Meas. Tech. | GLS Enzyme Potency Assay |
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IC50 | 20.0±n/a nM |
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Citation | Nissink, JW; Finlay, MR; Charles, MD 1,3,4-thiadiazole compounds and their use in treating cancer US Patent US10323028 Publication Date 6/18/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Glutaminase kidney isoform, mitochondrial |
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Name: | Glutaminase kidney isoform, mitochondrial |
Synonyms: | GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase |
Type: | Protein |
Mol. Mass.: | 73471.89 |
Organism: | Homo sapiens (Human) |
Description: | O94925 |
Residue: | 669 |
Sequence: | MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL
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BDBM416686 |
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n/a |
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Name | BDBM416686 |
Synonyms: | (2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide and (2R)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide | US10323028, Example 21(a) | US10981904, Example 44 |
Type | Small organic molecule |
Emp. Form. | C21H25N7O4S |
Mol. Mass. | 471.533 |
SMILES | CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1 |r| |
Structure |
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