| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 11 |
|---|
| Ligand | BDBM354745 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Radiometric Filter Plate MLK3 Assay |
|---|
| IC50 | >1000±n/a nM |
|---|
| Citation |  Gelbard, HA; Dewhurst, S; Gendelman, HE Mixed lineage kinase inhibitors for HIV/AIDS therapies US Patent US10485800 Publication Date 11/26/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase 11 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase 11 |
|---|
| Synonyms: | M3K11_HUMAN | MAP3K11 | MLK3 | Mitogen-activated protein kinase kinase kinase 11 | Mixed Lineage Kinase 3 (MLK3) | PTK1 | SPRK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 92696.93 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1460565 |
|---|
| Residue: | 847 |
|---|
| Sequence: | MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDEL
ALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLE
EVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALK
AVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR
DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFS
KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA
QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR
EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKR
SKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEP
GQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPL
GSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRD
LQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPV
GQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWS
FVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAP
WVPEAGP
|
|
|
|---|
| BDBM354745 |
|---|
| n/a |
|---|
| Name | BDBM354745 |
|---|
| Synonyms: | Preparation of 5-(3-(3-chloro-4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N,N-dimethylpyridin-2-amine | US10485800, Example 22 | US9814704, Example 22 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H16ClFN4 |
|---|
| Mol. Mass. | 366.819 |
|---|
| SMILES | CN(C)c1ccc(cn1)-c1cnc2[nH]cc(-c3ccc(F)c(Cl)c3)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
