| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 11 |
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| Ligand | BDBM420148 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radiometric Filter Plate MLK3 Assay |
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| IC50 | 550±n/a nM |
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| Citation |  Gelbard, HA; Dewhurst, S; Gendelman, HE Mixed lineage kinase inhibitors for HIV/AIDS therapies US Patent US10485800 Publication Date 11/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 11 |
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| Name: | Mitogen-activated protein kinase kinase kinase 11 |
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| Synonyms: | M3K11_HUMAN | MAP3K11 | MLK3 | Mitogen-activated protein kinase kinase kinase 11 | Mixed Lineage Kinase 3 (MLK3) | PTK1 | SPRK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 92696.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1460565 |
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| Residue: | 847 |
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| Sequence: | MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDEL
ALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLE
EVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALK
AVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR
DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFS
KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA
QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR
EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKR
SKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEP
GQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPL
GSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRD
LQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPV
GQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWS
FVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAP
WVPEAGP
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| BDBM420148 |
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| n/a |
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| Name | BDBM420148 |
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| Synonyms: | US10485800, Cmpd ID 6-(4-amino-3- methoxyphenyl)-1- cyclopentyl- 1H- imidazo[4,5- b]pyrazin- 2(3H)-one | US10485800, Example 118 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19N5O2 |
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| Mol. Mass. | 325.3651 |
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| SMILES | COc1cc(ccc1N)-c1cnc2[nH]c(=O)n(C3CCCC3)c2n1 |
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| Structure | 
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