| Reaction Details |
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 | Report a problem with these data |
| Target | ADP-ribosylhydrolase ARH3 |
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| Ligand | BDBM421498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ARH3 Assay |
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| IC50 | >100000±n/a nM |
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| Citation |  McGonagle, AE; Jordan, AM; Waszkowycz, B; Hutton, CP; Waddell, ID; Hitchin, JR; Smith, KM; Hamilton, NM PARG inhibitory compounds US Patent US10508086 Publication Date 12/17/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| ADP-ribosylhydrolase ARH3 |
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| Name: | ADP-ribosylhydrolase ARH3 |
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| Synonyms: | ADP-ribose glycohydrolase ARH3 | ADP-ribosylhydrolase 3 | ADPRHL2 | ADPRS | ADPRS_HUMAN | ARH3 | O-acetyl-ADP-ribose deacetylase ARH3 | Poly(ADP-ribose) glycohydrolase ARH3 | [Protein ADP-ribosylarginine] hydrolase-like protein 2 | [Protein ADP-ribosylserine] hydrolase |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38934.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NX46 |
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| Residue: | 363 |
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| Sequence: | MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEP
DPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGV
VTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQL
THASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEER
PYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNS
LQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVF
QKS
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| BDBM421498 |
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| n/a |
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| Name | BDBM421498 |
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| Synonyms: | US10508086, Example 88 | US10995073, Example 88 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20F2N6O3S3 |
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| Mol. Mass. | 526.603 |
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| SMILES | Cc1nc(C)c(Cn2c3ccc(cc3n(-c3nnc(s3)C(F)F)c2=O)S(=O)(=O)NC2(C)CC2)s1 |
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| Structure | 
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