| Reaction Details |
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 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] |
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| Ligand | BDBM287814 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | R132H IDH1 Enzymatic Assay |
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| IC50 | 97.0±n/a nM |
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| Citation |  Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Ellis, JM; Esposite, S; Hoffman, DM; Huang, C; Kattar, SD; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Reutershan, MH; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Wu, Z; Yu, Y; Gibeau, CR Tricyclic compounds as inhibitors of mutant IDH enzymes US Patent US10508108 Publication Date 12/17/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] |
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| Name: | Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] |
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| Synonyms: | Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) | IDH1 | IDH1 R132H | IDH1(R132H) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132H) | Isocitrate dehydrogenase 1 mutant (R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (R132H) | PICD |
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| Type: | Protein |
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| Mol. Mass.: | 46641.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human IDH1 R132H (SEQ ID No. 2 in patent). First three are removed. Google patent parsed wrong. |
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| Residue: | 414 |
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| Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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| BDBM287814 |
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| n/a |
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| Name | BDBM287814 |
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| Synonyms: | 6-[(3,5- difluorotricyclo[3.3.1.1~3,7~] dec-1-yl)carbonyl]-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine | US10086000, Example 32 | US10508108, Example 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30F2N4O2 |
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| Mol. Mass. | 480.5495 |
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| SMILES | FC12CC3CC(F)(C1)CC(C3)(C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |THB:2:3:8:7.11.1,10:3:7:8.11.9| |
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| Structure | 
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