Reaction Details | |||
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Target | Serine/threonine-protein kinase pim-1 | ||
Ligand | BDBM377199 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzyme Assay | ||
IC50 | <100±n/a nM | ||
Citation | Xue, C; Li, Y; Feng, H; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as PIM kinase inhibitors US Patent US10517858 Publication Date 12/31/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase pim-1 | |||
Name: | Serine/threonine-protein kinase pim-1 | ||
Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | ||
Type: | Protein | ||
Mol. Mass.: | 35681.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11309 | ||
Residue: | 313 | ||
Sequence: |
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BDBM377199 | |||
n/a | |||
Name | BDBM377199 | ||
Synonyms: | 3-Amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide | US10265307, Example 46-1 | US10517858, Example 46 (Diastereoisomer 1) | US11229631, Example 46 Diastereoisomer 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H27F3N6O2 | ||
Mol. Mass. | 512.5268 | ||
SMILES | C[C@@H]1C[C@H](N)CN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F |r,wU:12.13,3.3,1.0,(-.15,3.29,;-1.48,2.52,;-2.82,3.29,;-4.15,2.52,;-5.48,3.29,;-4.15,.98,;-2.82,.21,;-1.48,.98,;-2.82,-1.33,;-4.15,-2.1,;-5.61,-1.62,;-6.52,-2.87,;-5.61,-4.11,;-6.01,-5.6,;-4.15,-3.64,;-2.82,-4.41,;-1.48,-3.64,;-1.48,-2.1,;-.15,-1.33,;1.18,-2.1,;1.18,-3.64,;2.52,-1.33,;2.52,.21,;3.85,.98,;5.19,.21,;6.52,.98,;5.19,-1.33,;3.85,-2.1,;3.85,-3.64,;3.85,2.52,;2.52,3.29,;1.18,2.52,;2.52,4.83,;3.85,5.6,;5.19,4.83,;5.19,3.29,;6.52,2.52,)| | ||
Structure |