| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calmodulin-domain protein kinase 1, putative |
|---|
| Ligand | BDBM340941 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | luminescent kinase assay |
|---|
| IC50 | 2018±n/a nM |
|---|
| Citation |  Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent US10544104 Publication Date 1/28/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calmodulin-domain protein kinase 1, putative |
|---|
| Name: | Calmodulin-domain protein kinase 1, putative |
|---|
| Synonyms: | n/a |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 60946.72 |
|---|
| Organism: | Cryptosporidium parvum (strain Iowa II) |
|---|
| Description: | A3FQ16 |
|---|
| Residue: | 538 |
|---|
| Sequence: | MGNTAVGNTGTRLRAPVDAVVNTTNKKAPVSEKPSQPQIPNKTSDVKKGGTMGGERGSVT
TGMFVQSGSGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTI
LREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIK
QVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAY
YIAPEVLRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRT
ISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQA
EKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHEFMRLKGVDS
NSLIQNEGSTIEDQIDSLMPLLDMDGSGSIEYSEFIASAIDRTILLSRERMERAFKMFDK
DGSGKISTKELFKLFSQADSSIQMEELESIIEQVDNNKDGEVDFNEFVEMLQNFVRNE
|
|
|
|---|
| BDBM340941 |
|---|
| n/a |
|---|
| Name | BDBM340941 |
|---|
| Synonyms: | N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimidin-3-yl)phenyl)-2-phenylacetamide | US10544104, Compound 66 | US11247972, Compound 66 | US9765037, Compound 66 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H24N6O |
|---|
| Mol. Mass. | 400.4763 |
|---|
| SMILES | CC(C)(C)n1nc(-c2ccc(NC(=O)Cc3ccccc3)cc2)c2c(N)ncnc12 |
|---|
| Structure | 
|
|---|
Search and Browse
