| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 11 |
|---|
| Ligand | BDBM429899 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Time Resolved Fluorescence (TRF) Assay |
|---|
| IC50 | <500±n/a nM |
|---|
| Citation |  Lee, J; Burnette, P; Chellappan, S; Barczak, N; Escobedo, JA; Conti, C; Han, B; Lancia, Jr., DR; Liu, C; Martin, MW; Ng, PY; Rudnitskaya, A; Thomason, JR; Zheng, X Methods using HDAC11 inhibitors US Patent US10538496 Publication Date 1/21/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 11 |
|---|
| Name: | Histone deacetylase 11 |
|---|
| Synonyms: | HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 39187.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96DB2 |
|---|
| Residue: | 347 |
|---|
| Sequence: | MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
|
|
|
|---|
| BDBM429899 |
|---|
| n/a |
|---|
| Name | BDBM429899 |
|---|
| Synonyms: | US10538496, Compound II-5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18F4N2O3 |
|---|
| Mol. Mass. | 422.3728 |
|---|
| SMILES | ONC(=O)c1cccc2CC3(CCN(Cc4ccc(c(F)c4)C(F)(F)F)C3=O)Cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
