Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 11 |
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Ligand | BDBM433316 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SHP2 Phosphatase Assay |
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IC50 | <50±n/a nM |
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Citation | Xie, Y; Babiss, LE SHP2 inhibitors and uses thereof US Patent US10561655 Publication Date 2/18/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 11 |
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Name: | Tyrosine-protein phosphatase non-receptor type 11 |
Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
Type: | Protein phosphatase |
Mol. Mass.: | 68443.59 |
Organism: | Homo sapiens (Human) |
Description: | Q06124 |
Residue: | 593 |
Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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BDBM433316 |
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n/a |
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Name | BDBM433316 |
Synonyms: | (R)-3-(3-amino-3H- spiro[benzofuran-2,4'- piperidin]-1'-yl)-6-((2,3- dichlorophenyl)thio) pyrazin-2(1H)-one | US10561655, Compound 87 |
Type | Small organic molecule |
Emp. Form. | C22H20Cl2N4O2S |
Mol. Mass. | 475.391 |
SMILES | N[C@@H]1c2ccccc2OC11CCN(CC1)c1ncc(Sc2cccc(Cl)c2Cl)[nH]c1=O |r| |
Structure |
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