Reaction Details |
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Target | Diacylglycerol O-acyltransferase 2 |
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Ligand | BDBM435351 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Activity Assay |
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IC50 | 2932±n/a nM |
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Citation | Imbriglio, J; Liang, R; London, C; Marby, K; Tata, J; You, M; Xiong, Y Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US10568876 Publication Date 2/25/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol O-acyltransferase 2 |
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Name: | Diacylglycerol O-acyltransferase 2 |
Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 43848.90 |
Organism: | Homo sapiens (Human) |
Description: | Q96PD7 |
Residue: | 388 |
Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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BDBM435351 |
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n/a |
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Name | BDBM435351 |
Synonyms: | US10568876, Example 112 | methyl 3-(2-(2-phenylacetyl)-8-((2- phenylcyclopropanecarboxamido)methyl)- 1,2,3,4-tetrahydroisoquinolin-5- yl)benzoate (mixture of 4 isomers) |
Type | Small organic molecule |
Emp. Form. | C36H34N2O4 |
Mol. Mass. | 558.6662 |
SMILES | COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)Cc1ccccc1 |
Structure |
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