Reaction Details |
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Target | Estrogen receptor [307-554] |
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Ligand | BDBM361492 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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IC50 | 0.940±n/a nM |
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Citation | Nissink, JW; Scott, JS; Moss, TA; Hughes, SJ; Barlaam, BC; Yang, B Selective estrogen receptor down-regulators US Patent US10590132 Publication Date 3/17/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Estrogen receptor [307-554] |
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Name: | Estrogen receptor [307-554] |
Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen receptor(ER) (aa 307-554) | NR3A1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 28281.50 |
Organism: | Homo sapiens (Human) |
Description: | aa 307-554 |
Residue: | 248 |
Sequence: | ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPG
FVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFD
MLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTL
IHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDA
HRLHAPTS
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BDBM361492 |
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n/a |
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Name | BDBM361492 |
Synonyms: | 3-fluoro-N-(2- (2-fluoro-3- ((1R,3R)-2-((3- fluorooxetan- 3-yl)methyl)- 3-methyl- 2,3,4,9- tetrahydro-1H- pyrido[3,4- b]indol-1-yl)- 4- methoxyphenoxy) ethyl)propan- 1-amine | US10221173, Example 84 | US10590132, Example 84 | US11046689, Example 84 |
Type | Small organic molecule |
Emp. Form. | C28H34F3N3O3 |
Mol. Mass. | 517.5831 |
SMILES | COc1ccc(OCCNCCCF)c(F)c1[C@H]1N(CC2(F)COC2)[C@H](C)Cc2c1[nH]c1ccccc21 |r| |
Structure |
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