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TargetEstrogen receptor [307-554]
LigandBDBM361492
Substrate/Competitorn/a
Meas. Tech.Binding Assay
IC50 0.940±n/a nM
Citation Nissink, JWScott, JSMoss, TAHughes, SJBarlaam, BCYang, B Selective estrogen receptor down-regulators US Patent US10590132 Publication Date 3/17/2020
More Info.:Get all data from this article,  Assay Method
 
Estrogen receptor [307-554]
Name:Estrogen receptor [307-554]
Synonyms:ESR | ESR1 | ESR1_HUMAN | Estrogen receptor(ER) (aa 307-554) | NR3A1
Type:Enzyme Catalytic Domain
Mol. Mass.:28281.50
Organism:Homo sapiens (Human)
Description:aa 307-554
Residue:248
Sequence:
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPG
FVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFD
MLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTL
IHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDA
HRLHAPTS
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  Blast E-value cutoff:
BDBM361492
n/a
NameBDBM361492
Synonyms:3-fluoro-N-(2- (2-fluoro-3- ((1R,3R)-2-((3- fluorooxetan- 3-yl)methyl)- 3-methyl- 2,3,4,9- tetrahydro-1H- pyrido[3,4- b]indol-1-yl)- 4- methoxyphenoxy) ethyl)propan- 1-amine | US10221173, Example 84 | US10590132, Example 84 | US11046689, Example 84
TypeSmall organic molecule
Emp. Form.C28H34F3N3O3
Mol. Mass.517.5831
SMILESCOc1ccc(OCCNCCCF)c(F)c1[C@H]1N(CC2(F)COC2)[C@H](C)Cc2c1[nH]c1ccccc21 |r|
Structure
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