| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [T790M,L858R] |
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| Ligand | BDBM397142 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Omnia Assay Protocol |
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| IC50 | <10±n/a nM |
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| Citation |  Singh, J; Petter, RC; Tester, RW; Kluge, AF; Mazdiyasni, H; Westlin, III, WF; Niu, D; Qiao, L 2,4-disubstituted pyrimidines useful as kinase inhibitors US Patent US10596172 Publication Date 3/24/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [T790M,L858R] |
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| Name: | Epidermal growth factor receptor [T790M,L858R] |
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| Synonyms: | EGFR | EGFR (L858R, T790M) | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) (T790M/L858R) | Epidermal growth factor receptor (EGFR)(T790M/L858R) | Epidermal growth factor receptor (T790M)(L858R) | Epidermal growth factor receptor (T790M, L858R) | Epidermal growth factor receptor (T790M/L858R) | Epidermal growth factor receptor(L858R, T790M) | HER1 |
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| Type: | n/a |
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| Mol. Mass.: | 134353.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[T790M,L858R] |
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| Residue: | 1210 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
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| BDBM397142 |
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| n/a |
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| Name | BDBM397142 |
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| Synonyms: | US10596172, Compound I-1 | US10828300, Compound I-1 | US11351168, Compound I-1 | US9987276, Compound I-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N5O |
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| Mol. Mass. | 345.3978 |
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| SMILES | Cc1cccc(Nc2ccnc(Nc3cccc(NC(=O)C=C)c3)n2)c1 |
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| Structure | 
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