| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM385079 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Resonance Energy Transfer (FRET) Assay |
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| EC50 | 51.0±n/a nM |
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| Citation |  KC, SK; Mittapalli, GK; Chiruta, C; Hofilena, BJ; Mak, CC; Eastman, BW; Bollu, V 6-(5-membered heteroaryl)isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10604514 Publication Date 3/31/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM385079 |
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| n/a |
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| Name | BDBM385079 |
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| Synonyms: | US10287267, Compound 1086 | US10287267, Compound 1087 | US10287267, Compound 77 | US10287267, Compound 972 | US10508099, Compound 972 | US10556885, Compound 1087 | US10604514, Compound 6 | US11174244, Compound 972 | US11673881, Compound 77 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29N5O |
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| Mol. Mass. | 391.5093 |
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| SMILES | CC(C)CN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 |
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| Structure | 
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