Reaction Details |
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Target | Tryptophan 5-hydroxylase 2 |
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Ligand | BDBM445700 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Enzyme Activity Assay |
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IC50 | 30.0±4 nM |
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Citation | Bader, M; Specker, E; Matthes, S; Schütz, A; Mallow, K; Grohmann, M; Nazaré, M Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same US Patent US10683309 Publication Date 6/16/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Tryptophan 5-hydroxylase 2 |
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Name: | Tryptophan 5-hydroxylase 2 |
Synonyms: | NTPH | TPH2 | TPH2_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 56055.12 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_487490 |
Residue: | 490 |
Sequence: | MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE
SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI
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BDBM445700 |
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n/a |
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Name | BDBM445700 |
Synonyms: | Ex. 36/KM-06-164/(I-36) | US10683309, Example 36 | US11028104, Example 36 |
Type | Small organic molecule |
Emp. Form. | C26H29N7O3 |
Mol. Mass. | 487.5536 |
SMILES | CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)N3CCCC3=O)c2c(=O)[nH]c1=O |
Structure |
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