| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [837-1142] |
|---|
| Ligand | BDBM400439 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In vitro JAK Kinase Assay |
|---|
| IC50 | <5.00±n/a nM |
|---|
| Citation |  Huang, T; Xue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent US10695337 Publication Date 6/30/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK1 [837-1142] |
|---|
| Name: | Tyrosine-protein kinase JAK1 [837-1142] |
|---|
| Synonyms: | JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 35230.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23458[837-1142] |
|---|
| Residue: | 306 |
|---|
| Sequence: | FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDP
EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIM
EFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQ
VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT
YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQP
SNRTSF
|
|
|
|---|
| BDBM400439 |
|---|
| n/a |
|---|
| Name | BDBM400439 |
|---|
| Synonyms: | US10695337, Example 194 | US11285140, Example 194 | US9999619, Example 194 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H29N11O |
|---|
| Mol. Mass. | 535.603 |
|---|
| SMILES | Cn1c(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
