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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Non-receptor tyrosine-protein kinase TYK2 [871-1187] | ||
| Ligand | BDBM449881 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| EC50 | 443±n/a nM | ||
| Citation |  Larsen, J; Larsen, M; Rasmussen, LK; Ritzen, A; Duus, TM Amino-imidazopyridine derivatives as Janus kinase inhibitors and pharmaceutical use thereof US Patent US10703751 Publication Date 7/7/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Non-receptor tyrosine-protein kinase TYK2 [871-1187] | |||
| Name: | Non-receptor tyrosine-protein kinase TYK2 [871-1187] | ||
| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 | Non-receptor tyrosine-protein kinase TYK2 (871-1187) | TYK2 | TYK2 (aa 871-1187) | TYK2_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 36255.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P29597[871-1187] | ||
| Residue: | 317 | ||
| Sequence: |
| ||
| BDBM449881 | |||
| n/a | |||
| Name | BDBM449881 | ||
| Synonyms: | US10703751, Example 7 | cis-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(methylamino)imidazo[4,5-c]pyridin-1-yl]cyclohexyl]acetonitrile | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H23N5O | ||
| Mol. Mass. | 313.3974 | ||
| SMILES | CNc1cc2n([C@@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O |r,wU:20.24,6.5,9.9,(-2.67,-3.81,;-1.34,-4.58,;-.01,-3.81,;-.01,-2.27,;1.33,-1.5,;1.65,0,;.62,1.15,;1.09,2.61,;.06,3.76,;-1.44,3.44,;-2.48,4.58,;-3.98,4.26,;-5.49,3.94,;-1.92,1.97,;-.89,.83,;3.18,.17,;3.8,-1.24,;2.66,-2.27,;2.66,-3.81,;1.33,-4.58,;3.95,1.5,;3.18,2.83,;5.49,1.5,)| | ||
| Structure | 
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