| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
|---|
| Ligand | BDBM398149 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Pore Permeation Assay |
|---|
| IC50 | 55±n/a nM |
|---|
| Citation |  Karra, SR Indole derivatives and their use in neurodegenerative diseases US Patent US10676433 Publication Date 6/9/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 7 |
|---|
| Name: | P2X purinoceptor 7 |
|---|
| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68602.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q99572 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
|
|
|
|---|
| BDBM398149 |
|---|
| n/a |
|---|
| Name | BDBM398149 |
|---|
| Synonyms: | (S)-4-chloro-N-((3,3-difluoro-1-hydroxycyclohexyl)methyl)-1-(oxetan-3-yl)-1H-indole-3-carboxamide | US10323000, Compound 85 | US10676433, Compound 85 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21ClF2N2O3 |
|---|
| Mol. Mass. | 398.831 |
|---|
| SMILES | O[C@@]1(CNC(=O)c2cn(C3COC3)c3cccc(Cl)c23)CCCC(F)(F)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
