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TargetSolute carrier family 22 member 12
LigandBDBM181133
Substrate/Competitorn/a
Meas. Tech.URAT1 activity
IC50>300000±n/a nM
Citation Piwinski, JJ; Siddiqui, A; Warrell, Jr., RP Compounds and their use for reducing uric acid levels US Patent US10752613 Publication Date 8/25/2020
More Info.:Get all data from this article,  Assay Method
 
Solute carrier family 22 member 12
Name:Solute carrier family 22 member 12
Synonyms:OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:Enzyme
Mol. Mass.:59638.65
Organism:Homo sapiens (Human)
Description:Q96S37
Residue:553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
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  Blast E-value cutoff:
BDBM181133
n/a
NameBDBM181133
Synonyms:US10093658, Compound Allopurinol | US10752613, Compound Allopurinol | US11021454, Compound Allopurinol | US9138393, Allopurinol | US9144538, Allopurinol
TypeSmall organic molecule
Emp. Form.C5H4N4O
Mol. Mass.136.1115
SMILESOc1ncnc2[nH]ncc12
Structure
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