| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cell division cycle 7-related protein kinase/Protein DBF4 homolog A |
|---|
| Ligand | BDBM458736 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| IC50 | <1000±n/a nM |
|---|
| Citation |  Zhang, H Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents US Patent US10745410 Publication Date 8/18/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cell division cycle 7-related protein kinase/Protein DBF4 homolog A |
|---|
| Name: | Cell division cycle 7-related protein kinase/Protein DBF4 homolog A |
|---|
| Synonyms: | Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase | CDC7 and DBF4 | CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Protein DBF4 homolog A |
|---|
| Synonyms: | ASK | Activator of S phase kinase | Chiffon homolog A | DBF4 | DBF4-type zinc finger-containing protein 1 | DBF4A | DBF4A_HUMAN | Protein DBF4 homolog A | ZDBF1 |
|---|
| Type: | Regulatory subunit |
|---|
| Mol. Mass.: | 76869.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 674 |
|---|
| Sequence: | MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTI
SEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPH
PSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIE
QKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMP
FINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCL
QKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSP
VSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPS
NELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVD
HYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQ
EHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRT
EFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLT
AFFSSPSTSTFTGF
|
|
|
|---|
| Component 2 |
| Name: | Cell division cycle 7-related protein kinase |
|---|
| Synonyms: | CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 63908.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00311 |
|---|
| Residue: | 574 |
|---|
| Sequence: | MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI
EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV
KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP
SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG
PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH
ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC
SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD
LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ
GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD
EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
|
|
|
|---|
| BDBM458736 |
|---|
| n/a |
|---|
| Name | BDBM458736 |
|---|
| Synonyms: | (S)-2-(1-amino-2- methylpropyl)-6- (pyrimidin-4-yl)thieno [3,2-d]pyrimidin-4(3H)- one hydrochloride | US10745410, Code 53 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H15N5OS |
|---|
| Mol. Mass. | 301.367 |
|---|
| SMILES | CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1ccncn1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
