| Reaction Details |
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 | Report a problem with these data |
| Target | Period circadian protein homolog 2 |
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| Ligand | BDBM356961 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | High-Throughput Assay |
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| EC50 | 986±n/a nM |
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| Citation |  Bersot, R; Humphries, P Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators US Patent US10759777 Publication Date 9/1/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Period circadian protein homolog 2 |
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| Name: | Period circadian protein homolog 2 |
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| Synonyms: | Circadian clock protein PERIOD 2 | KIAA0347 | PER2 | PER2_HUMAN | Period circadian protein homolog 2 | hPER2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 136576.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116705 |
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| Residue: | 1255 |
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| Sequence: | MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTGRDSQGSDCDD
SGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQSSKVDTHKELIKTLKELKV
HLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPSYTVEEMES
VTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVGVFH
SFTSPYKLPLWSMCSGADSFTQECMEEKSFFCRVSVRKSHENEIRYHPFRMTPYLVKVRD
QQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQD
LIETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINP
WSRKISFIIGRHKVRVGPLNEDVFAAHPCTEEKALHPSIQELTEQIHRLLLQPVPHSGSS
GYGSLGSNGSHEHLMSQTSSSDSNGHEDSRRRRAEICKNGNKTKNRSHYSHESGEQKKKS
VTEMQTNPPAEKKAVPAMEKDSLGVSFPEELACKNQPTCSYQQISCLDSVIRYLESCNEA
ATLKRKCEFPANVPALRSSDKRKATVSPGPHAGEAEPPSRVNSRTGVGTHLTSLALPGKA
ESVASLTSQCSYSSTIVHVGDKKPQPELEMVEDAASGPESLDCLAGPALACGLSQEKEPF
KKLGLTKEVLAAHTQKEEQSFLQKFKEIRKLSIFQSHCHYYLQERSKGQPSERTAPGLRN
TSGIDSPWKKTGKNRKLKSKRVKPRDSSESTGSGGPVSARPPLVGLNATAWSPSDTSQSS
CPAVPFPAPVPAAYSLPVFPAPGTVAAPPAPPHASFTVPAVPVDLQHQFAVQPPPFPAPL
APVMAFMLPSYSFPSGTPNLPQAFFPSQPQFPSHPTLTSEMASASQPEFPSRTSIPRQPC
ACPATRATPPSAMGRASPPLFQSRSSSPLQLNLLQLEEAPEGGTGAMGTTGATETAAVGA
DCKPGTSRDQQPKAPLTRDEPSDTQNSDALSTSSGLLNLLLNEDLCSASGSAASESLGSG
SLGCDASPSGAGSSDTSHTSKYFGSIDSSENNHKAKMNTGMEESEHFIKCVLQDPIWLLM
ADADSSVMMTYQLPSRNLEAVLKEDREKLKLLQKLQPRFTESQKQELREVHQWMQTGGLP
AAIDVAECVYCENKEKGNICIPYEEDIPSLGLSEVSDTKEDENGSPLNHRIEEQT
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| BDBM356961 |
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| n/a |
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| Name | BDBM356961 |
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| Synonyms: | 1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxy-2- methylpropyl)-3,3- difluoropyrrolidin-2- one | US10214507, Compound 59 | US10759777, Compound 59 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18F4N2O2 |
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| Mol. Mass. | 394.3627 |
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| SMILES | CC(O)(CN1CCC(F)(F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12 |
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| Structure | 
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